Anti-CD43 antibody Rabbit monoclonal

Code: SAB5500067-100UL D2-231

Application

Anti-CD43 antibody, Rabbit monoclonal has been used in immunohistochemistry.

Biochem/physiol Actions

Cluster of differentiation 43 (C...


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Your Price
€395.20 100UL
Discontinued
€486.10 inc. VAT

Application

Anti-CD43 antibody, Rabbit monoclonal has been used in immunohistochemistry.

Biochem/physiol Actions

Cluster of differentiation 43 (CD43) is known to regulate cell cycle and cell relocation in both lymphoid and non-lymphoid tumor cells. It serves as a biomarker in chronic lymphocytic leukemia and other hematologic cancer diagnosis. CD43 is associated with cell movement, cell differentiation, apoptosis and immune homeostasis. Glycosylation and sialylation of CD43 at extracellular C-terminus, enables its purpose as a ligand for selectins. CD43 promotes extracellular signal-regulated kinase 1/2 (ERK 1/2) signaling, which is necessary for actin cytoskeleton modifications. CD43 is associated with autoimmune diseases, including systemic lupus erythematosus, diabetes, human immunodeficiency virus (HIV) infection and Wiskott-Aldrich syndrome.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

CD43 is one of the major glycoproteins of thymocytes and T lymphocytes. It plays a role in the physicochemical properties of the T cell surface and in lectin binding. CD43 presents carbohydrate ligands to selectins. It has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. The antigen is a counter receptor for SN/Siglec1. During T cell activation CD43 is actively removed from the T cell antigen presenting cell contact site suggesting a negative regulatory role in adaptive immune response.

The SPN (sialophorin) gene is mapped to human chromosome 16p11.2 and encodesa transmembrane sialoglycoprotein cluster of differentiation 43 (CD43). It is localized to the surface of leukocytes and is expressed in hematopoietic cells. CD43 protein structure possesses a 23-amino acid transmembrane bridge connecting the N- and C- terminal regions. Its cytoplasmic tail is highly conserved.

Immunogen

Synthetic peptide derived from the human CD43.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
cloneSP55, monoclonal
conjugateunconjugated
Gene Informationhuman ... SPN(6693)
isotypeIgG
Quality Level100
recombinantexpressed in proprietary host
shipped inwet ice
species reactivityhuman (tested)
storage temp.2-8°C
technique(s)flow cytometry: 1:100, immunohistochemistry: 1:200, immunoblotting: 1:25
UniProt accession no.P16150
This product has met the following criteria to qualify for the following awards:



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